Research

Projects: Protein Bio-Analysis, Clinical Assays, Biomarkers & Mass Spectrometry

  • Analysis of Cancer Stem Cell Pathways in Tissues
  • Identification of Surface Markers for Identification of Cancer Stem Cells
  • Interactions of the Micro-Environment with Cancer Stem Cells
  • Therapeutics for Cancer Stem Cells
  • Markers of Cancer in Serum and Urine Using a Glycoproteomics Approach
  • Mass Spectrometry Analysis of Glycoproteins and Glycans
  • Development of MRM Assays for Glycoproteins in Serum Using Electrospray and MALDI-MS
  • Analysis of Cancer Cells and Serum for Unique Single Nucleotide Polymorphisms Associated with Cancer
  • Marker Studies for Crohns and Colitis
  • Studies of the Bacterial Microbiome in the Gut and its Relationship to Cancer and Inflammation

 

New Methodology for Solving Biological Problems

  • Development of 2-D Liquid Phase Separation Using pI as the 1st Dimension and Non-Porous RP-HPLC as the 2nd Dimension (Please See News Release For More Info)
  • Development of New Nonporous Rapid RP-HPLC Methods for Analysis of Whole Cell Lysates of Proteins to Replace 2-D Gel Electrophoresis
  • Development of Capillary Electrophoresis and Capillary Electrochromatography for High Resolution Separation of Proteins and Protein Digests
  • Analysis of Large Proteins and DNA by Laser (MALDI/MS Analysis)
  • Whole Cell Screening by Direct MALDI/MS
  • Interface of Gel Electrophoresis to MALDI/MS
  • High Resolution - On-Line - LC/MS Using Electrospray MS Methods
  • Tandem MS Methods
  • Capillary Gel Electrophoresis/MALDI-MS of Complex Cell Proteins
  • Affinity Separations-MALDI/ESI/MS